role of the nitrergic system of the cuneiform nucleus in cardiovascular responses in urethane-anesthetized male rats

Authors

esmaeil farrokhi department of physiology, faculty of medicine, mashhad university of medical sciences, mashhad, iran

mohammad naser shafei neurogenic inflammation research center, mashhad university of medical sciences, mashhad, iran

abolfazl khajavirad department of physiology, faculty of medicine, mashhad university of medical sciences, mashhad, iran; and neurogenic inflammation research center, mashhad university of medical sciences, mashhad, iran

mahmoud hosseini neurocognetive research center, mashhad university of medical sciences, mashhad, iran

abstract

background: the presence of nitric oxide (no) in the cuneiform nucleus (cnf) has been previously shown. in this study, ng-nitro-l-arginine methyl ester (l-name) (an inhibitor of no synthase), l-arginine (l-arg) (a precursor of no), and sodium nitroprusside (snp) (a donor of no) were microinjected into the cnf and cardiovascular responses were investigated. methods: seventy male rats were divided into 7 groups (n=10 each): 1) saline, 2 and 3) l-name (30 and 90 nmol), 4 and 5) l-arg (20 and 60 nmol), and 6 and 7) snp (9 and 27 nmol). after anesthesia, the femoral artery was cannulated and cardiovascular parameters were recorded using a powerlab system. time course changes in mean arterial pressure (δmap) and heart rate (δhr) were calculated and compared with those in the control group (repeated measures anova). maximum ∆map and ∆hr were also compared with those in the control group (independent sample t test). results: ∆map with both doses of l-name (30: p=0.026 and 90: p=0.007) and ∆hr with the higher dose (p=0.034) were significantly higher than those in the control group. maximal ∆map with both doses (p<0.01 and p<0.001, n=10) and maximal ∆hr with the higher dose (p<0.01) were significantly higher than those in the control group. changes in l-arg with both doses were not significantly higher than those in the control group (p=0.26, n=8). ∆map and ∆hr of snp only with the higher dose were significantly lower than those in the control group (p=0.006 and p=0.035), and maximal responses with the higher dose were lower than those in the control group (∆map: p<0.01 and ∆hr: p<0.05, n=7). conclusion: our results showed that the nitrergic system of the cnf had an inhibitory effect on central cardiovascular regulation.

Upgrade to premium to download articles

Sign up to access the full text

Already have an account?login

similar resources

Role of the Nitrergic System of the Cuneiform Nucleus in Cardiovascular Responses in Urethane-Anesthetized Male Rats

Background: The presence of nitric oxide (NO) in the cuneiform nucleus (CnF) has been previously shown. In this study, NG-nitro-L-arginine methyl ester (L-NAME) (an inhibitor of NO synthase), L-arginine (L-Arg) (a precursor of NO), and sodium nitroprusside (SNP) (a donor of NO) were microinjected into the CnF and cardiovascular responses were investigated. Methods: Seventy male rats were divide...

full text

Role of the Nitrergic System of the Cuneiform Nucleus in Cardiovascular Responses in Urethane-Anesthetized Male Rats

Background The presence of nitric oxide (NO) in the cuneiform nucleus (CnF) has been previously shown. In this study, NG-nitro-L-arginine methyl ester (L-NAME) (an inhibitor of NO synthase), L-arginine (L-Arg) (a precursor of NO), and sodium nitroprusside (SNP) (a donor of NO) were microinjected into the CnF and cardiovascular responses were investigated. Methods Seventy male rats were divide...

full text

Cardiovascular effects of nitrergic system of the pedunculopon-tine tegmental nucleus in anesthetized rats

Objective(s): Nitric oxide (NO) is an important neurotransmitter in central nervous system involved in central cardiovascular regulation. The presence of NO in the pedunculopontine tegmental (PPT) nucleus has been shown, but its cardiovascular effect has not been determined. In the present study, the cardiovascular effect of NO in the PPT nucleus was evaluated. Materials and Methods: After indu...

full text

the effect of aqueous extract of garlic on formalin-induced pain in male rats

چکیده اثر عصاره آبی سیر بر درد ناشی از آزمون فرمالین در موش صحرایی نر به کوشش نرگس اسکندری روزبهانی زمینه و هدف: گیاه سیر از خانواده لیلیاسه و گونهallium sativum بومی آسیای میانه بوده و از دوران ،باستان تاکنون به خواص درمانی متفاوت آن مثل: کاهندگی قندخون، کلسترول خون، فشار خون، اثرات مفیدآن بر دستگاه قلبی عروقی و بیماریهای انعقادی خون، اثرات آنتی اکسیداتیو، درمان بیماریهای تنفسی وگوارشی، ا...

15 صفحه اول

the analysis of the role of the speech acts theory in translating and dubbing hollywood films

از محوری ترین اثراتی که یک فیلم سینمایی ایجاد می کند دیالوگ هایی است که هنرپیش گان فیلم میگویند. به زعم یک فیلم ساز, یک شیوه متأثر نمودن مخاطب از اثر منظوره نیروی گفتارهای گوینده, مثل نیروی عاطفی, ترس آور, غم انگیز, هیجان انگیز و غیره, است. این مطالعه به بررسی این مسأله مبادرت کرده است که آیا نیروی فراگفتاری هنرپیش گان به مثابه ی اعمال گفتاری در پنج فیلم هالیوودی در نسخه های دوبله شده باز تولید...

15 صفحه اول

the role of thematic structure in comprehending spoken language

in fact this study is concerned with the relationship between the variation in thematice structure and the comprehension of spoken language. so the study focused on the following questions: 1. is there any relationship between thematic structure and the comprehension of spoken language? 2. which of the themes would have greated thematic force and be easier for the subjects to comprehend? accord...

15 صفحه اول

My Resources

Save resource for easier access later


Journal title:
iranian journal of medical sciences

جلد ۴۱، شماره ۲، صفحات ۰-۰

Hosted on Doprax cloud platform doprax.com

copyright © 2015-2023